Association of the ITGA4 rs1143674 polymorphism with subclinical atherosclerosis in patients with ulcerative colitis over 40 years of age
Background: Patients with ulcerative colitis (UC) have an increased cardiovascular risk due to chronic inflammation and endothelial dysfunction. The ITGA4 gene encodes the α4 integrin subunit, a key regulator of leukocyte adhesion to endothelium. The ITGA4 rs1143674 genetic variant has been associated with coronary ath...