Conditioning Intensity and Outcomes in Pediatric HLA-Identical Transplant for Sickle Cell Disease: Comparison of MAC, RIC, and NMA.
BACKGROUND Children with sickle cell disease (SCD) increasingly undergo HLA-identical sibling donor hematopoietic cell transplant (HCT), yet the optimal conditioning intensity remains uncertain. Myeloablative conditioning (MAC) has been the conventional approach, but reduced-intensity conditioning (RIC) and nonmyeloabl...