Author

A. Akinyemi

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Review Oct 2026

Non-histone protein lactylation in cancer metastasis: From metabolic reprogramming to therapeutic targeting.

How non-histone lactylation regulates the metastatic cascade is synthesized using a three-tier confidence framework distinguishing fully characterized circuits from proteomic screening hits, and therapeutic strategies ranging direct lactylation machinery inhibitors from indirect lactate-axis modulators are discussed.

Mithu Howlader, A. Akinyemi, Md Rakibul Alam et al. · Biochemical Pharmacology · 0 citations

Open access Sep 2026

CDK1-mediated phosphorylation of APE1 drives synthetic lethality, p53-dependent metastasis, and immune sensitization in NSCLC

Cyclin-dependent kinase 1 (CDK1), a serine/threonine kinase essential for cell cycle progression, also plays critical roles in DNA damage response, gene expression regulation, and therapeutic resistance. In this study, we identify a previously unrecognized regulatory link between CDK1 and apurinic/apyrimidinic endonu...

Jian-Lin Wang, Jiang Li, Jia Peng et al. · Cell Death & Disease · 0 citations

Review Sep 2026

BRN2 in Lineage Plasticity: A Prostate Cancer-Focused Perspective.

This review examines how BRN2 connects developmental neurogenesis to therapy-induced tumor reprogramming and integrates insights from neurodevelopment and direct lineage reprogramming to describe how BRN2 maintains stem-like and neuroendocrine transcriptional states.

Fatemeh Seilani, Jia Peng, Meng Wu et al. · Endocrinology · 0 citations