Open access
Sep 2026
Chemical induction and reversal of photoreceptor dystrophy in retinal organoids.
Activating transcription factor 6 (ATF6) controls a signal transduction pathway of the unfolded protein response (UPR). Loss-of-function ATF6 mutations cause inherited photoreceptor diseases. Ceapin-A7 is a non-toxic, cell-permeable small molecule that selectively inhibits ATF6. We investigated how ATF6 inhibition impa...
Allyssa Bradley, Hyejung Min, Soyoung Park et al.
· Stem Cell Reports · 0 citations