IKK16 and SGI1027 induce cytoplasmic vacuolization, and their combination with chemotherapy drugs can enhance the efficacy of cancer therapeutics
Cell death represents a critical process in the maintenance of cellular homeostasis. Paraptosis, a mechanism of programmed cell death, is distinguished by extensive cytoplasmic vacuolization. We have identified two commercially available compounds, IKK16 and SGI1027, which can induce cytoplasmic vacuolization leading...