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Author

A. Almehdi

2 papers indexed here

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Review Open access Sep 2026

Purine nucleoside phosphorylase in breast cancer from metabolic regulation to targeted therapy: challenges and opportunities.

Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine salvage pathway that has recently emerged as a potential therapeutic target in cancer. While its role in hematological malignancies is relatively well established, its contribution to solid tumors, particularly breast cancer, remains insufficiently def...

Sahar Salem, Rania Hamdy, Sarra B. Shakartalla et al. · 0 citations
Aug 2026

Synthesis, Cytotoxicity, and Docking Studies of Novel Chalcones Incorporating 2‐(1 H ‐Indol‐1‐yl)‐ N ‐arylacetamide and Benzo[ d ]thiazole Moieties

A new series of benzothiazole–chalcone–indole N ‐arylacetamide hybrids ( 7a–e ) was designed, synthesized, and spectroscopically characterized as potential anticancer agents. Their antiproliferative activity was evaluated by MTT assay against HCT‐116, MCF‐7, HepG2, and Hep2 cancer cell lines, alongside normal W...

Noha Yehia Badr, A. Almehdi, Mohamed A. Ragheb et al. · 0 citations

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