Author

A. Arab

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Open access Sep 2026

Chemogenomic maps reveal a PRDX1-dependent iron-damage axis in the DNA damage response.

The DNA damage response (DDR) is a sophisticated network of cellular pathways whose perturbation leads to genome instability and is a key hallmark of oncogenesis. Here, we present data from 32 genome-scale loss-of-function CRISPR interference chemical-genetic screens with inhibitors targeting core constituents of the D...

T. O'Loughlin, A. Arab, Sara Misiukiewicz et al. · Nature Chemical Biology · 0 citations

Open access Aug 2026

A Dimeric Protein-RNA Glue Promotes Multivalent eIF4A-RNA Assembly

BisRoc is identified, a dimeric rocaglate ligand that potently and durably suppresses translation and exhibits greater specificity across a cancer cell line panel than the monomeric RocA.

Jie Liu, Megan K. Moore, Kevin Lou et al. · ACS Central Science · 0 citations