Author

A. Asiaee

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Review Open access Aug 2026

Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation

HLA class I alleles confer a striking risk for T cell–mediated drug hypersensitivity, yet positive predictive values are low—typically under 10% and as low as 0.12% for some drug–HLA pairs. We propose that persistent, human-adapted pathogens—notably herpesviruses—focus postnatal immune memory on conserved epitopes in t...

Simon Mallal, A. Asiaee, E. Phillips · Pathogens and Immunity · 2 citations

Review Aug 2026

Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design

We propose that persistent, human-adapted DNA organisms shape postnatal immunity by focusing responses on functionally constrained epitopes within tissue niches. Here, we examine rapidly evolving RNA viruses and tumors through that lens. We propose that their persistence is promoted by 2 coupled mechanisms: (i) immunod...

Simon Mallal, Amir Asiaee · Pathogens and Immunity · 3 citations