B-cell maturation antigen -targeted Tirapazamine-loaded liposomes overcome hypoxia-induced drug resistance and metastasis in multiple myeloma.
Multiple myeloma (MM) is a highly fatal disease, particularly in the relapsed-refractory stage, due to drug resistance associated with tumor hypoxia. TPZ, a hypoxia-activated pro-drug, effectively kills hypoxic tumor cells; however, its severe side effects have limited its therapeutic use. This study investigates BCMA-...