Open access
Aug 2026
RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis
Together, these findings identify TUT4/7 as druggable targets, whose inactivation suppresses AML while sparing normal hematopoiesis, and represents a promising therapeutic strategy in combination with venetoclax.
Christopher Mapperley, Elise Georges, A. Azar et al.
· Science Advances · 0 citations