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Open access Sep 2026

Causal roles of phenotypic age and metabolic health on dementia: a Mendelian randomisation and structure learning study

Background Phenotypic age acceleration (PhenoAgeAccel), derived from PhenoAge, and MetaboHealth are composite exposures of biological ageing and metabolic health associated with dementia-related outcomes. Whether these associations are causal and reflect the exposures, constituent biomarkers, or both remains unclear. M...

A. Baousi, K. Dobinda, J. Zhu et al. · 0 citations
Open access Sep 2026

Genetic Architecture and Sample Size Impact Relative Performance of Nonlinear Machine Learning and Standard Polygenic Risk Scores

Standard polygenic risk scores (PRSs) are constructed based on additive genome-wide association study (GWAS) summary statistics. Nonlinear machine learning methods have been increasingly applied to construct PRSs directly from individual-level data, with the aim of improving predictive performance over standard PRSs th...

J. Zhu, A. Baousi, A. P. Morris et al. · 0 citations

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