Author

A. Barozet

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Open access Sep 2026

Antibody CDR-H3 loop flexibility: Insights from X-ray crystallography, structural bioinformatics, and the limits of current deep learning methods.

Complementarity Determining Regions (CDRs) in antibodies, and in particular the CDR-H3 loop, often display conformational plasticity that is essential for their function. Due to this flexibility, the structural investigation of antibody-antigen binding cannot exclusively rely on experimental techniques that only provid...

Amélie Barozet, M. Mathieu, David Papin et al. · Journal of Structural Biolog... · 0 citations

Open access Sep 2026

BOTANIC-1: a series of long-context plant genomic foundation models in the agentic era

The Botanic1 family of gLMs designed for plant research is presented, which operates reliably on sequences from hundreds of base pairs up to 128 kbp, and integrates Botanic1 as a specialised genomic layer callable by a generalist large language model (LLM) agent, illustrating how such hybrid systems could accelerate pl...

Amélie Barozet, V. Cabeli, Jean Ogier du Terrail et al. · bioRxiv · 1 citation

#small language model Open access Sep 2026

BOTANIC-1: a series of long-context plant genomic foundation models in the agentic era

The development of climate-resilient crops would be greatly accelerated by models able to reason directly over plant genomic sequences and to pinpoint trait-associated regions or loci. Anticipating the impact of DNA base changes (variants) remains challenging, and understanding regulatory mechanisms is still an active...

A. Barozet, V. Cabeli, J. D. du Terrail et al. · bioRxiv · 0 citations