Author

A. Beggs

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Open access Sep 2026

PBF/PTTG1IP coordinates focal adhesion formation, polarity and cell motility

Directional cell migration requires cells to sense extracellular cues and coordinate adhesion, cytoskeletal remodelling and polarity, yet the molecular regulators that integrate these events remain incompletely defined. PTTG1-binding factor (PBF/PTTG1IP) is a transmembrane glycoprotein extensively characterised in path...

Merve Kocbiyik, Selvambigai Manivannan, Davina Banga et al. · bioRxiv · 0 citations

Open access Aug 2026

IGF2BP3-mediated regulation of the RNA isoform and modification landscape in pancreatic cancer.

The incidence of pancreatic ductal adenocarcinoma (PDAC) is increasing but clinical outcomes remain poor and new treatments are required. IGF2BP3 is an oncofetal m6A-reading RNA regulatory protein whose expression is commonly observed in PDAC and which may represent an important therapeutic target. IGF2BP3 protein is e...

Sandra Margielewska-Davies, W. Croft, Hayden Pearce et al. · Oncogene · 0 citations