Alzheimer’s disease (AD) co-pathology is common in dementia with Lewy bodies (DLB) and has been linked to poorer outcomes. However, its associations with domain-specific cognitive performance across the MCI/prodromal and dementia stages, and the relationship between cognitive performance and plasma biomarkers, re...
Elena Vera-Campuzano, Í. Rodríguez-Baz, Carla Abdelnour et al.· Alzheimer's Research & T...· 0 citations
White matter signal abnormalities (WMSA) on MRI are common in dementia with Lewy bodies (DLB), and more severe WMSA have been associated with increased neurodegeneration in DLB. However, the underlying mechanisms of WMSA remain unclear. Single-Shell 3-Tissue Constrained Spherical Deconvolution (SS3T-CSD) is a d...
Anna Rennie, M. Němý, A. Badji et al.· Alzheimer's Research & T...· 0 citations
BACKGROUND
As individuals with Down syndrome age, they face high risks of Alzheimer's disease and epilepsy. With symptomatic Alzheimer's disease, late-onset myoclonic epilepsy in Down syndrome (LOMEDS) often emerges. We aimed to examine how epilepsy develops in Down syndrome, its timing relative to Alzheimer's disease...
Lucía Maure-Blesa, M. Carmona-Iragui, I. Barroeta et al.· The Lancet· 1 citation
Introduction Semantic cognition, our ability to understand meaning, relies on two distinct but interacting systems: one involved in knowledge representation and another in control processes. This control system is thought to comprise at least two mechanisms: controlled retrieval, which facilitates access to information...
Pilar Armas, A. Morcillo-Nieto, Sara E. Zsadanyi et al.· Frontiers in Aging Neuroscie...· 0 citations
Prior English-language research to Spanish is extended, demonstrating that morphosyntactic and transitivity deficits are a robust and cross-linguistically consistent feature of neurodegenerative language decline, and highlighting the importance of developing language-sensitive assessment tools for underrepresented ling...
S. Mancini, N. Biondo, M. Calabria et al.· medRxiv· 0 citations
There is a need for early, objective markers of Alzheimer's disease (AD)‐related synapse dysfunction in adults with Down syndrome (DS). The presynaptic protein β‐synuclein is elevated in the blood of adults with DS. This study evaluates the positioning of these changes relative to changes in pathophysiological blood bi...
Alba Cervantes González, A. Morcillo-Nieto, Sara Serrano et al.· Alzheimer's & Dementia· 0 citations
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration constitute a clinico‐genetic‐neuropathological continuum with marked heterogeneity and large, multimodal cohorts are needed to advance biomarker discovery and precision medicine.
Á. Carbayo, J. Turon-Sans, D. Alcolea et al.· Alzheimer's & Dementia· 0 citations
A double-cutoff analysis suggest that scans in the 11 to 26 Centiloid range should be interpreted with caution depending on the context of use, and positivity cutoffs converged around 18 Centiloids (data-driven) and 27 Centiloids (visual reads).
G. Blazhenets, D. Soleimani-Meigooni, Konstantinos Chiotis et al.· Journal of the American Medi...· 5 citations
These findings highlight the complementary roles of CSF and plasma tau biomarkers in tracking disease progression: CSF biomarkers capture early pathological changes, whereas plasma biomarkers more effectively reflect disease progression within symptomatic stages.
J. Arranz, J. Lantero-Rodríguez, Luisa Sophie Braun-Wohlfahrt et al.· EBioMedicine· 1 citation
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