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A. Beliaev

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Open access Oct 2026

Structure-Guided Discovery of High-Affinity Methotrexate Aptamers for Electrochemical Drug Monitoring

Methotrexate (MTX) is a narrow-therapeutic-index drug widely used in cancer and autoimmune disease treatment, for which delayed clearance can cause severe toxicity and requires close therapeutic drug monitoring. Here, we integrate high-stringency Capture-SELEX, biophysical characterization, molecular modeling, mutation...

Micaela B. Sequera, Thiago C. Pimenta, Rafael Vieira et al. · 0 citations

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