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Author

A. M. Bendel

2 papers indexed here

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Open access Sep 2026

A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin

While protein ubiquitination has been extensively studied, the roles of unanchored ubiquitin and its chains remain less understood, largely due to a lack of specific, high-affinity tools for their enrichment and visualization. To address this, we used high-throughput affinity maturation and computational protein design...

Shi-Hua Shi, A. Bendel, G. Kempf et al. · 0 citations
Open access Aug 2026

Proteome-wide identification of the druggable CRBN interactome.

This pipeline identified 6 known and 43 novel CRBN-pomalidomide binders, including orthogonally validated hits that provide privileged starting points for MGD development, and expects this binding-focused workflow to be applicable to other MGD-E3 ligase systems, potentially extending the scope of this emerging drug cla...

Pius Galli, Shuhao Xiao, Y. Meng et al. · 1 citation

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