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Open access Sep 2026

Functional Genomic Screening Identifies lncRNA CNPY2-AS1 as a Regulator of Redox Metabolism and Antiviral Immunity

The human genome encodes thousands of long non-coding RNAs (lncRNAs) that regulate innate immunity and viral life cycles, yet their roles in viral entry remain understudied. Here, we conducted a genome-wide CRISPR interference screen to identify lncRNAs that regulate SARS-CoV-2 entry. We identified two lncRNAs that mod...

Carolina Khoury, Tahleel Ali-Nasser, Yuval Ben Eliahu et al. · 0 citations
Open access Aug 2026

RNA-Lexis: a probabilistic algorithm using a non-parametric segmentation logic to detect meaningful sequences in RNA

RNA-Lexis provides a statistically grounded and interpretable framework for motif-level analysis of lncRNAs, rather than directly inferring function, the method identifies recurrent sequence architecture and prioritizes candidate elements for mechanistic testing.

H. Bar, Amit Felach, A. Bester · 0 citations

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