Open access
Aug 2026
EWSR1::FLI1 promotes neocentromere formation in ewing sarcoma cells
SUMMARY Ewing sarcoma (EwS) is characterized by chimeric fusions such as EWSR1::FLI1. Chromosome gain or loss is prevalent in EwS, and this chromosome instability (CIN) phenotype correlates with poor treatment outcomes. We previously showed that CENP-A, a centromere-specific histone H3 variant, interacts with EWSR1 via...
R. Kitagawa, Ediri E Metitiri, Bin Yu et al.
· Cell Reports · 0 citations