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Review Open access Oct 2026

Towards a suitable biomarker for childhood screening for familial hypercholesterolemia: a systematic literature review

Abstract Familial hypercholesterolemia (FH) is a common genetic disorder causing elevated low-density lipoprotein cholesterol (LDL-c) concentrations from birth, resulting in a high risk of premature cardiovascular disease. Despite effective early treatment, FH remains underdiagnosed in children, highlighting the need f...

Vera H. de Kleijne, B. Hutten, A. Boelen et al. · 0 citations
Aug 2026

Diminished Pro-Inflammatory Characteristics in Murine Bone Marrow Derived Macrophages with Impaired Thyroid Hormone Receptor Alpha 1 Signaling

Background: Macrophages are versatile phagocytes of the innate immune system with functions ranging from pro-inflammatory to immunomodulatory. Macrophages are receptive to signals from thyroid hormones (THs). Here, we studied the role of the TH receptor (TR)α1 in macrophage function. Methods: Using wild type (WT) and t...

Esmée Hoen, Kim Falize, A. Jongejan et al. · 0 citations

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