Open access
Oct 2026
Overcoming technological and biological barriers to pulmonary mRNA delivery with lipid-polymer hybrid nanoparticles.
Delivering mRNA to the lungs promises treatment of genetic, infectious and non-communicable lung diseases. Yet, conventional lipid nanoparticle formulations lack the stability needed to endure the harsh mechanical stress during nebulization. Additionally, once deposited in the respiratory tract, gene delivery systems m...
Achim Biesel, Aparna Shandheep, A. Pavlou et al.
· Journal of Controlled Releas... · 0 citations