Proton minibeam radiation therapy induces distinct metabolic and synaptic remodelling in rats with orthotopic glioblastoma.
PURPOSE Glioblastoma (GB) is an aggressive primary brain tumour with limited therapeutic options. Although radiotherapy (RT) remains a cornerstone of treatment, its efficacy is constrained by collateral damage to healthy brain tissue. Proton minibeam radiotherapy (pMBRT), a spatially fractionated modality, has shown pr...