HERC2–UBE3A structure uncovers a domain-motif protein network potentially altered in Angelman and related syndromes
UBE3A and HERC2 are two mutually interacting HECT E3 Ubiquitin ligases whose genes are altered in 15q11.2-13.1 Duplication (Dup15q) Syndrome, Angelman Syndrome (AS) and other phenotypically-related syndromes associated with intellectual disability. Using quantitative binding assays, X-ray crystallography and sequence c...