Review
Open access
Aug 2026
Advances in antisense technology for cardiovascular drug discovery: from gene silencing to therapeutics.
The principles that shape cardiovascular ASO candidate development are discussed, with emphasis on mechanism selection, chemical design, and exposure feasibility, and sequence optimization with exposure-informed target qualification and therapeutic-index engineering throughout ASO candidate selection.
D. Park, A. Bühler, Christian Schöllhorn et al.
· Expert Opinion on Drug Disco... · 0 citations