Author

A. C. C. Aguiar

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Open access Sep 2026

An mRNA-lipid nanoparticle vaccine targeting the Plasmodium vivax E140 antigen

Plasmodium vivax (Pv) remains the primary cause of malaria outside Africa, yet no licensed vaccine is available against this pathogen. Here, we evaluate the immunogenicity and protective efficacy of novel vaccines targeting E140, a recently identified multi-stage antigen conserved across Plasmodium species. Lipid nanop...

R. F. Marques, Guilherme Antonio de Souza Silva, Vitor Antunes da Silva et al. · Molecular Therapy: Nucleic A... · 0 citations

Open access Oct 2026

Rational Design of N‐2‐(7‐Chloroquinolin‐4‐ylamino)ethyl Amides Active Against Chloroquine‐Resistant Plasmodium falciparum

ABSTRACT Motivated by the antimalarial potential demonstrated by benzamide derivatives of 4‐alkylamino‐7‐chloroquinolines against chloroquine‐resistant Plasmodium falciparum, we designed and synthesized a rational series of N‐2‐(7‐chloroquinolin‐4‐ylamino)ethyl amides to investigate the effects of electron‐withdrawing...

Everton P. Silva, Camila S. Barbosa, A. C. C. Aguiar et al. · Archiv der Pharmazie · 0 citations