Dose-related effects of olezarsen in hypertriglyceridaemia: a systematic review and meta-analysis of 2,610 patients
Hypertriglyceridaemia is characterised by accumulation of triglyceride-rich lipoproteins (TRLs) contributing to residual atherosclerotic cardiovascular risk. Olezarsen is a GalNAc-conjugated antisense oligonucleotide targeting hepatic ApoC-III mRNA, thereby lowering ApoC-III and accelerating TRL clearance. We per...