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Allergic asthma results from an uncontrolled type 2 immune response to inhaled allergens. Here, we investigate the function of CD97/ADGRE5, expressed in mouse and human immune and lung epithelial cells, in this disease. Female Cd97−/− mice exhibit an exacerbated asthmatic phenotype across multiple models, primarily due...
It is found that the majority of the placental T cells are maternal and that the fetal T cells are only naïve or unconventional T cells (γδT cell subsets and MAIT cells).
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