Open access
Sep 2026
Calpain-Dependent Protein Degradation Contributes to CASQ2-R33Q CPVT
Couplon protein loss in CPVT associated with CASQ2-R33Q is mediated by coordinated but distinct proteolytic pathways, with calpain-dependent TRDN degradation representing a key pathogenic event that promotes CASQ2 destabilization and arrhythmogenesis.
Laura Ramos-Hernández, D. J. Santiago, Rocío F. Serrano-Blanco et al.
· Circulation Research · 0 citations