Open access
Aug 2026
Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State
It is shown that mitochondrial aging creates a vulnerable metabolic environment that, combined with specific triggers, can push cells toward early tumorigenesis, offering a new framework for understanding and intervening in age-related cancer risk.
Bibi Amina, Zainab Nasir, Rida Nasir Butt et al.
· Biology · 0 citations