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Open access Oct 2026

Interplay of Depletion Interaction and Viscosity Drives Non-monotonic Ligand Binding to DNA G-Quadruplex under Crowding

Study of ligand binding to G-quadruplex (G4) DNA under molecular crowding is essential for understanding its implications in cellular contexts; however, the underlying mechanism remains largely unresolved. We investigate the binding of 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPy...

A. Chand, Pramod Kumar, H. Sahu et al. · 0 citations
Preprint Sep 2026

Universal 1/f Noise in the Power Spectra of Energy Time-series in Solvated DNA Dynamics

We investigate energy fluctuations of solvated DNA in three conformations: G-quadruplex, Hairpin, and Duplex. Our comprehensive molecular dynamics (MD) simulations demonstrate that the time-series of interaction energies for DNA self, DNA-water and DNA-ion show 1/f noise with a universal decay exponent $\beta \simeq 0....

H. Sahu, Deepika Sardana, Pramod Kumar et al. · 0 citations

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