A. Chandra

A Novel Mechanistic Route to the Formation of an Internal Aldimine between Pyridoxal 5′-Phosphate and Ornithine Decarboxylase Enzyme at Its Active Site

Pyridoxal 5′-phosphate (PLP) functions as a vital cofactor in numerous biochemical processes. To perform its role as a cofactor, PLP has to first form a Schiff base complex with the enzyme, known as the internal aldimine, which is an important step for the function of all PLP dependent enzymes. In this study, we inve...