Stabilization of nucleic acid-based systems is critical for their clinical translation in biomedical applications. Here, we integrated hairpins within the edges of a DNA tetrahedron and studied the stabilization induced by these motifs against nucleases. We show that nuclease resistance of DNA tetrahedra increased with...
Sarah Youssef, Lauren A. Anderson, Meng-Yao Zheng et al.· bioRxiv· 0 citations
DNA nanotechnology has proven to have strong potential in several applications. This technology relies on the programmable nature of DNA self-assembly to build structures and motifs with a high level of precision. Most assembly techniques rely on a temperature gradient that might not be suitable for all applications, e...
Hannah Talbot, Sarah Youssef, A. Chandrasekaran· JACS Au· 0 citations
DNA nanotechnology offers architectures ranging from compact motifs to scaffolded origami, with trade-offs in structural complexity, addressability, and component economy. Here, we translate Leonardo da Vinci's mazzocchio geometry into a programmable DNA assembly. Twenty distinct DNA strands hierarchically assemble int...
S. C. Shiu, Hannah Talbot, Marcello DeLuca et al.· Nano letters (Print)· 0 citations
Functionalizing DNA nanostructures for stimuli-responsive reconfiguration has been a key area of development in DNA nanotechnology. Here, we demonstrate programmable control over the structural integrity of a tetrahedral DNA nanostructure using an external DNA stimulus that is modulated through an intermediate CRISPR...
Shubhajit Singha, M. Yigit, A. Chandrasekaran· Biochemistry· 0 citations
This work develops a potential method to construct more biostable DNA nanostructures and 3D crystals in a simple one-tube process by assembly of a wide variety of DNA nanostructures and 3D crystals in a hydrated ionic liquid instead of magnesium at constant moderate temperatures.
