Open access
Aug 2026
Dual immunomodulatory effects of bacteroides and phocaeicola secretomes revealed by integrative metabolomic and functional screening in HT-29 cells
Background The immunomodulatory effects of gut Bacteroides are typically attributed to surface polysaccharides signaling through TLR2 and TLR4, and to outer membrane vesicles (OMVs) that traffic effector molecules to host cells. However, these bacteria also secrete a wide array of metabolites, including short-chain fat...
Irina Podoprigora, N. Zakharzhevskaya, M. Das et al.
· Frontiers in Microbiology · 0 citations