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Open access Sep 2026

Indirect comparative efficacy and safety of tirzepatide vs semaglutide for the treatment of obesity or overweight in patients without type 2 diabetes.

BACKGROUND/OBJECTIVES Tirzepatide is a once-weekly, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) for obesity treatment. This indirect treatment comparison (ITC) assessed the relative efficacy and safety of tirzepatide versus the GLP-1 RA semaglutide. SUBJECTS/...

A. Ciudin, Erin Johansson, S. Zimner-Rapuch et al. · 0 citations
Open access Aug 2026

Longitudinal Changes in Body Composition, Adaptive Thermogenesis and Muscle Strength in Patients with Obesity Treated with Semaglutide.

BACKGROUND Obesity management increasingly emphasizes not only total weight reduction but also the quality of weight loss, reflecting the balance between fat and lean tissue changes, preservation of strength capacity, and changes in energy expenditure. Semaglutide is effective for weight management, yet its integrated...

Francesca Filippi-Arriaga, M. Comas, Anna Prats et al. · 0 citations

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