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Á. Cobo-Calvo

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Review Open access Aug 2026

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum...

J. Villacieros-Álvarez, Carmen Espejo, G. Arrambide et al. · 0 citations
Sep 2026

Refining Treatment Monitoring in Patients With Relapsing Multiple Sclerosis Based on Changes on Neurofilament Light Chain Z-Scores.

Failure to reduce zNfL levels after 1 year of treatment was associated with subsequent disease activity, even in patients otherwise considered stable, providing complementary information to clinical and MRI-based monitoring.

Victoria Fernández, A. Pappolla, P. Carbonell-Mirabent et al. · 1 citation
Review Open access Aug 2026

De-Escalating and Discontinuing Immunotherapies in Patients With NMOSD and MOGAD

Treatment de-escalation is sometimes necessary because of adverse effects, comorbidities, infections, treatment fatigue, or life circumstances such as pregnancy, but in pregnancy, management requires balancing maternal disease control with fetal safety, with strategies ranging from continuation of selected therapies to...

Y. Hacohen, G. Androdias, G. Arrambide et al. · 0 citations
Review Open access Aug 2026

Use of Fluid Biomarkers in NMOSD and MOGAD

A review of current evidence on established and emerging fluid biomarkers in NMOSD and MOGAD, with emphasis on analytical performance, biological relevance, and clinical utility, and outlines priorities for future research.

S. Mariotto, Á. Cobo-Calvo, M. Khalil et al. · 0 citations

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