Review
Open access
Aug 2026
The role of mitochondrial dysfunction and genetics in female infertility and premature ovarian insufficiency.
BACKGROUND Female infertility occurs in ∼37% of infertile couples, while premature ovarian insufficiency (POI) impacts 1-3.7% of women under the age of 40. POI is clinically heterogeneous, with various genetic pathways associated with its pathogenesis. Mitochondrial diseases (MDs) are a broad group of clinically hetero...
Brianna L Kline, A. Compton, A. E. Frazier et al.
· Human Reproduction Update · 0 citations