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Open access Oct 2026

DCAF7 regulates hematopoietic stem cell function and differentiation through polycomb repressive complex 1 modulation

DCAF7 is one of the few DCAFs expressed in hematopoietic stem cells (HSCs). Using a conditional knockout mouse model, we discovered that the absence of DCAF7 leads to accumulation of differentiating progenitors in the bone marrow, and impairs self-renewal capacity of HSCs upon transplantation. Furthermore, loss of Dcaf...

Johanna Melo-Cardenas, Lavanya Bezavada, Te Ling et al. · 0 citations

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