Antibody Recognition and Functional Activity Against a Conserved Trypanosoma cruzi Peptide and Its Natural Variants in Kinetoplastids
The TcTLE peptide (TLEEFSAKL), located at the amino-terminus of the Trypanosoma cruzi Kinetoplastid Membrane Protein-11 (KMP-11), induces robust humoral and cellular immune responses, suggesting its potential for serological diagnostics or immunoprophylaxis. However, natural variants of this sequence exist in Leishmani...