Open access
Aug 2026
Cytotoxic CD4+ T cells induce age-associated myelopoiesis through CCL5-CCR5 signaling.
Age-associated hematopoietic skewing results in an increase in the neutrophil-to-lymphocyte ratio, which serves as a strong predictor of all-cause mortality in older adults, although its causes are incompletely understood. Here we show that cytotoxic CD4+ T lymphocytes accumulate in the bone marrow of mice during aging...
E. Gabandé-Rodríguez, G. Soto-Heredero, Elisa Carrasco et al.
· Nature Aging · 0 citations