Open access
2026
Reclassification of variants of uncertain significance in genes associated with hereditary breast cancer in patients treated at referral hospitals in the state of Goiás
Introduction: Breast cancer is the most common malignancy among women, with 5–10% of cases arising from hereditary predisposition, driven by pathogenic variants in DNA repair genes such as BRCA1/BRCA2, as well as moderate-risk genes, including ATM, CHEK2, TP53, BARD1, and BRIP1. Next-generation sequencing improves vari...
Bruno Eduardo Feitosa Nascimento, I. M. Calassa, Luiz Henrique Alves Costa et al.
· Mastology · 0 citations