Review
Open access
Sep 2026
Eighty Years After Vague: Advances in Understanding Ectopic Fat and Metabolic Dysfunction.
The distribution of adipose tissue is a key determinant of obesity-related disease risk. When the capacity of subcutaneous adipose tissue to safely store energy is exceeded, lipid overflow into visceral depots occurs, increasing free fatty acid flux, promoting insulin resistance, and triggering chronic low-grade inflam...
Caterina Conte, P. Sumithran, C. L. le Roux et al.
· Obesity Reviews · 0 citations