Open access
Sep 2026
Transcription pause and elongation regulators mediate somatic hypermutation.
Somatic hypermutation (SHM) creates point mutations in the variable regions of immunoglobulin genes in activated B cells to support antibody affinity maturation1. SHM is initiated by activation-induced deaminase (AID), and the single-stranded DNA substrate of this cytosine deaminase is thought to arise during RNA polym...
Li-Zhen Wu, A. D. Yadavalli, Caillan C. McAuliffe et al.
· Nature · 1 citation