Background Schizophrenia (SZ) is a heterogeneous disorder characterized by positive, negative, cognitive and disorganisation symptoms, with pleomorphic phenotype and poorly understood aetiology. Dopamine dysregulation represents the most replicated in vivo pathophysiology finding. However, accumulating evidence suggest...
Matteo Vitacca, D. Pischedda, M. Ciccarelli et al.· bioRxiv· 0 citations
TRS is characterized by the most severe impairments in GABA-A receptor-mediated inhibition and the highest levels of cortical hyperexcitability and inhibitory deficits, alongside shared plasticity impairments across schizophrenia subtypes.
A. Barone, G. Senerchia, G. De Simone et al.· International Journal of Neu...· 0 citations
Abstract Background About a third of schizophrenia patients are refractory to antipsychotics, a condition characterized by poor clinical and functional outcomes known as treatment-resistant schizophrenia (TRS). The disorganization domain may represent the leading factor in categorizing a schizophrenia patient as affect...
M. Ciccarelli, F. Iasevoli, A. Barone et al.· International Journal of Neu...· 0 citations
The impaired cholesterol metabolism in SCZ patients is associated with a pro-inflammatory state, which is responded to by the anti-inflammatory remodeling of HDL subfractions, and improving intestinal cholesterol absorption and reducing endogenous cholesterol biosynthesis could represent putative therapeutic approaches...
S. Bagnasco, G. De Simone, G. Cernera et al.· International Journal of Mol...· 0 citations
Overall agreement is good, supporting its potential role in standardising psychopathology evaluation, and LLM-assisted scoring could enhance reproducibility in psychiatric research and offer scalable support in the clinical assessment of SCZ and TRS.
F. Iannotta, L De Santis, A. Catino et al.· International Journal of Neu...· 0 citations
A reorganization of molecular networks in schizophrenia is demonstrated, with alterations in the micro-architecture of molecular couplings, strengthening the importance of investigating functional interactions among molecules, as such analyses may reveal significant alterations in schizophrenia that cannot be detected...
G. De Simone, T. Nuzzo, A. di Maio et al.· International Journal of Neu...· 0 citations
Findings suggest that increased expression of these miRNAs may enhance gene silencing across synaptic and intracellular signaling cascades, potentially contributing to impaired neuroplasticity and treatment resistance through downregulation of critical neurotransmission-related targets.
L. Vellucci, P. Mirra, A. Nasti et al.· International Journal of Neu...· 0 citations
The Fusiform Gyrus appears to function as a dynamic, state-sensitive hub underlying perceptual, emotional, and cognitive disturbances in schizophrenia, in line with impaired ToM.
M. Ciccarelli, B. Mazza, A. Nasti et al.· Neuroscience and Biobehavior...· 0 citations
The observed pattern of impairment is consistent with that described in chronic schizophrenia and clinical high-risk states for psychosis, confirming that these domains are frequently altered along the continuum of Neurodevelopmental Syndromes (NDS).
C. Ceparano, F. Iannotta, C. Ricci et al.· International Journal of Neu...· 0 citations
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