A. De Sario

Epigenome-wide association study and functional analyses reveal regulatory loci linked to lung function and diabetes in cystic fibrosis

While the genetic basis of cystic fibrosis is well-established, the genotype alone does not explain the substantial inter-individual variability in disease expression, particularly in pulmonary outcomes. Non-hereditary factors, such as epigenetic modifications, may contribute to this clinical heterogeneity....