Background DNA methylation (DNAm) based age acceleration is an indicator of biological ageing. However, it is unclear how age acceleration is linked to mental health in adolescents. We examined the longitudinal associations between DNAm age acceleration and depression and anxiety in adolescents. We also triangulated th...
C. Shen, O. Robinson, P. Vineis et al.· medRxiv· 0 citations
This work proposes a framework for identifying confounders of two non-causally related traits by employing cross-trait pleiotropy analysis to detect genetic loci that affect both traits and multi-trait colocalisation to identify molecular phenotypes mediating these effects.
J. Yarmolinsky, F. Cavallo, F. Koskeridis et al.· medRxiv· 0 citations
Plasma proteins are promising biomarkers and potential drug targets in psoriasis. We conducted a two-sample Mendelian randomisation analysis integrating protein quantitative trait loci from UK Biobank and deCODE genetics with a psoriasis GWAS meta-analysis of 36,466 cases. To strengthen causal inference, we performed c...
D. Meena, C. V. Chalitsios, J. Huang et al.· medRxiv· 0 citations
BACKGROUND
Disinfection by-products, including those arising from secondary reactions between chlorinated reagents and natural organic matter such as trihalomethanes (THMs), have been associated with several adverse health outcomes, such as bladder and colorectal cancer.
AIMS
We aim to identify metabolic signatures o...
Sibo Lucas Cheng, P. Keski-Rahkonen, A. C. Chatziioannou et al.· Environment International· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
