Author

A. Dehghan

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Open access Nov 2026

Human genetic investigation of TMPRSS6 as a therapeutic target for liver disease: efficacy and safety liabilities

Human genetic evidence supports hepatic iron lowering by TMPRSS6 inhibition, but not an effect on steatosis, and the CAD signal, partly mediated by LDL cholesterol, warrants careful consideration in trial design.

M.-J. Dib, M. Vujkovic, S. Burgess et al. · medRxiv · 0 citations