Three-fraction preoperative stereotactic radiotherapy for resectable brain metastases: the phase 2 STEP trial.
BACKGROUND Postoperative stereotactic radiotherapy (SRT) is the standard adjuvant treatment after resection of brain metastases. It nevertheless requires delineation of a dynamic postsurgical cavity, delays local treatment by 3 to 6 weeks (and thus resumption of systemic therapy) and carries substantial risks of radiat...