Open access
Oct 2026
IgM-and IgG-cleaving enzyme facilitates AAV gene transfer in AAV-seropositive macaques.
AAV gene therapy is a promising approach for long-term delivery of antiviral proteins that can control HIV replication, but pre-existing circulating AAV-specific antibodies can preclude successful AAV transduction and pose a challenge for AAV vector re-administration in cases where transgene protein expression falls be...
Helen L. Wu, Z. Elmore, Mark A. Ochoa et al.
· Frontiers in Immunology · 0 citations