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Author

A. Drzazga

2 papers indexed here

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Open access Sep 2026

Sphinganine as a novel stimulator of GLP-1 secretion.

AIMS/HYPOTHESIS Mechanisms of secretion of the gut hormone glucagon-like peptide-1 (GLP-1) remain incompletely understood yet are relevant for the pathophysiology and treatment of obesity and diabetes. Here, we set out to identify novel triggers. METHODS We started with using metabolomics on plasma samples from meal...

Mark M. Smits, A. Drzazga, Jarkko J. Lackman et al. · 0 citations
Open access Sep 2026

Non-canonical cleavage of GPR125/ADGRA3 releases extracellular receptor fragments detectable in cerebrospinal fluid

Summary Adhesion G protein-coupled receptors (aGPCRs) are crucial for barrier tissues and typically autoproteolytically cleaved into N- and C-terminal fragments (NTF and CTF) that remain non-covalently associated until separation is triggered. Here, we show that human GPR125 (ADGRA3), expressed in choroid plexus epithe...

Anna L. S. Walser, O. Larsen, Chiara Stüdle et al. · 0 citations

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