Mitochondrial-Mediated Apoptosis and Anti-Leukemic Effects of Tocotrienol Within the Protective Bone Marrow Microenvironment
Abstract Purpose: Acute Myeloid Leukemia (AML) is a highly aggressive hematological malignancy driven by mutations in early hematopoietic cells, leading to uncontrolled myeloid cell proliferation. The development of efficacious and less toxic therapies remains a critical challenge. Methods: Herein, we evaluated the ant...