From genomic instability to epigenetic regulation: the role of DNA repair gene variants and non-coding RNAs in colorectal carcinogenesis.
Colorectal cancer (CRC) pathogenesis is a multi-step process characterized by a transition from genomic instability to complex epigenetic regulation, wherein DNA repair gene variants and non-coding RNAs (ncRNAs) play a critical role in carcinogenesis. By synthesizing data on chromosomal instability (CIN), signal transd...